Parkinson''div-gpt-ad-1450190541376-0''div-gpt-ad-1450190541376-1''s the latest to raise concerns over drugs called proton pump inhibitors (PPIs). They include prescription and over-the-counter drugs like Prilosec (omeprazole), Prevacid (lansoprazole) and Nexium (esomeprazole). And they rank among the top-selling medications in the United States.
Research in recent years has linked prolonged PPI use to increased risks of various diseases and premature death.
These latest findings point to the specific causes of death tied to the drugs, said lead researcher Dr. Ziyad Al-Aly.
He stressed that the excess risks were relatively small. For example, over 10 years, 13% of PPI users died of a cardiovascular condition, including heart disease or stroke. That compared with just over 11% of people who used H2 blockers, another class of heartburn drug.
When the researchers weighed other factors—such as patients'' medical records, many of those with PPI prescriptions had no documented need for one.
"" said Al-Aly, an assistant professor at Washington University School of Medicine in St. Louis.
"" he said. ""
But an expert not involved in the study said it''s governing board. He said the current study, like others before it, is ""—that is, it used medical records to track patients''d used the drugs for at least a year, versus those who''s esophagus—serious damage to the esophageal lining that can raise the risk of cancer.
Before you start a PPI, Al-Aly said, be sure you actually need one. The drugs are available over the counter, but they should not be used for more than a couple weeks without talking to a doctor, he said.
If you''s knowledge.
The findings were published recently in the journal BMJ. The veterans in the study—mostly older men—started on a PPI or H2 blocker between 2002 and 2004.
Over the next 10 years, 38% of PPI for 1 last update 2020/07/04 users died, as did nearly 36% of those on H2 blockers.Over the next 10 years, 38% of PPI users died, as did nearly 36% of those on H2 blockers.
If PPIs contribute to deaths, it''s immune function and normal bacterial makeup.
The U.S. National Institute on Diabetes and Digestive and Kidney Diseases has more on treating GERD
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Citation: Heartburn drugs again tied to fatal risks (2019, June 6) retrieved 8 December 2019 from https://medicalxpress.com/news/2019-06-heartburn-drugs-tied-fatal.html
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